Algebra-2

Question Analysis
This problem tests the student's understanding of applying Descartes' Rule of Signs to determine the possible number of negative real roots of a polynomial.

Key Concept Explanation
To find the number of negative real roots, we first substitute into the polynomial and then count the number of sign changes in the sequence of coefficients of the resulting polynomial.

Step-by-step Solution
1. Substitute into the polynomial:
2. Simplify the expression: